abstract：INTRODUCTION:Identifying appropriate pre-exposure prophylaxis (PrEP) candidates is a challenge in planning for the safe and effective roll-out of this strategy. We explored the use of a validated HIV risk screening tool, HIV Incidence Risk Index for Men who have Sex with Men (HIRI-MSM), to identify "optimal" candidates...

journal_title：Journal of the International AIDS Society

authors： Wilton J,Kain T,Fowler S,Hart TA,Grennan T,Maxwell J,Tan DH

更新日期：2016-06-03 00:00:00

abstract：INTRODUCTION:We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal, South Africa. METHODS:Individuals ≥16 years were offered HBHCT; tho...

journal_title：Journal of the International AIDS Society

authors： Plazy M,Farouki KE,Iwuji C,Okesola N,Orne-Gliemann J,Larmarange J,Lert F,Newell ML,Dabis F,Dray-Spira R,Anrs 12249 Tasp Study Group.

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Antiretroviral treatment (ART) has been scaled up over the last decade but compared to adults, children living with HIV are less likely to receive ART. Moreover, children and adolescents are more vulnerable than adults to virological failure (VF) and emergence of drug resistance. In this study we determine...

journal_title：Journal of the International AIDS Society

authors： Salou M,Dagnra AY,Butel C,Vidal N,Serrano L,Takassi E,Konou AA,Houndenou S,Dapam N,Singo-Tokofaï A,Pitche P,Atakouma Y,Prince-David M,Delaporte E,Peeters M

更新日期：2016-04-27 00:00:00

abstract：INTRODUCTION:For many women living with HIV (WLWH), the disclosure of positive status can lead to either an extension of former violence or new conflict specifically associated with HIV status disclosure. This study aims to explore the following about WLWH: 1. the women's experiences of intimate partner violence (IPV) ...

journal_title：Journal of the International AIDS Society

authors： Colombini M,James C,Ndwiga C,Integra team.,Mayhew SH

更新日期：2016-03-31 00:00:00

abstract：INTRODUCTION:Ethiopia has recently adopted lifelong antiretroviral therapy (ART) for all HIV-positive pregnant and breastfeeding women (Option B+ strategy), regardless of CD4 count or clinical stage. However, the exact timing and predictors of loss to follow-up (LFU) are unknown. Thus, we examined the levels and determ...

journal_title：Journal of the International AIDS Society

authors： Mitiku I,Arefayne M,Mesfin Y,Gizaw M

更新日期：2016-03-21 00:00:00

abstract：INTRODUCTION:International investment in the response to HIV and AIDS has plateaued and its future level is uncertain. With many countries committed to ending the epidemic, it is essential to allocate available resources efficiently over different response periods to maximize impact. The objective of this study is to p...

journal_title：Journal of the International AIDS Society

authors： Shattock AJ,Kerr CC,Stuart RM,Masaki E,Fraser N,Benedikt C,Gorgens M,Wilson DP,Gray RT

更新日期：2016-02-23 00:00:00

abstract：INTRODUCTION:In the Microbicide Trial Network MTN-003 (VOICE) study, a Phase IIB pre-exposure prophylaxis trial of daily oral or vaginal tenofovir (TFV), product adherence was poor based on pharmacokinetic (PK) drug detection in a random subsample. Here, we sought to compare behavioural and PK measures of adherence and...

journal_title：Journal of the International AIDS Society

authors： van der Straten A,Brown ER,Marrazzo JM,Chirenje MZ,Liu K,Gomez K,Marzinke MA,Piper JM,Hendrix CW,MTN-003 VOICE Protocol Team for Microbicide Trials Network.

更新日期：2016-02-04 00:00:00

abstract：INTRODUCTION:HIV infection impairs maintenance of immunological memory, yet few studies of HIV-positive adults receiving 7-valent pneumococcal conjugate vaccine (PCV7) have followed them beyond the first year. We determined and compared the durability of serological responses and the clinical outcomes of HIV-positive a...

journal_title：Journal of the International AIDS Society

authors： Cheng A,Chang SY,Tsai MS,Su YC,Liu WC,Sun HY,Hung CC

更新日期：2016-01-29 00:00:00

abstract：INTRODUCTION:In 2012, the Supreme Court of Canada ruled that people living with HIV (PLWH) must disclose their HIV status to sexual partners prior to sexual activity that poses a "realistic possibility" of HIV transmission for consent to sex to be valid. The Supreme Court deemed that the duty to disclose could be avert...

journal_title：Journal of the International AIDS Society

authors： Patterson SE,Milloy MJ,Ogilvie G,Greene S,Nicholson V,Vonn M,Hogg R,Kaida A

更新日期：2015-12-22 00:00:00

abstract：INTRODUCTION:Treatment as prevention has mobilized new opportunities in preventing HIV transmission and has led to bold new UNAIDS targets in testing, treatment coverage and transmission reduction. These will require not only an increase in investment but also a deeper understanding of the dynamics of combining behavio...

journal_title：Journal of the International AIDS Society

authors： Brown G,Reeders D,Dowsett GW,Ellard J,Carman M,Hendry N,Wallace J

更新日期：2015-12-14 00:00:00

abstract：INTRODUCTION:In 2014 the Joint United Nations Programme on HIV/AIDS defined the ambitious 90-90-90 targets for 2020, in which 90% of people living with HIV must be diagnosed, 90% of those diagnosed should be on sustained therapy and 90% of those on therapy should have an undetectable viral load. Children are considered...

journal_title：Journal of the International AIDS Society

authors： Rabie H,Frigati L,Hesseling AC,Garcia-Prats AJ

更新日期：2015-12-02 00:00:00

abstract：INTRODUCTION:Despite significant gains in access to early infant diagnosis (EID) over the past decade, most HIV-exposed infants still do not get tested for HIV in the first two months of life. For those who are tested, the long turnaround time between when the sample is drawn and when the results are returned leads to ...

journal_title：Journal of the International AIDS Society

authors： Essajee S,Vojnov L,Penazzato M,Jani I,Siberry GK,Fiscus SA,Markby J

更新日期：2015-12-02 00:00:00

abstract：INTRODUCTION:Women living with HIV experience a disproportionate burden of mental health issues. To date, global guidelines contain insufficient guidance on mental health support, particularly regarding perinatal care. The aim of this article is to describe the extent and impact of mental health issues as experienced b...

journal_title：Journal of the International AIDS Society

authors： Orza L,Bewley S,Logie CH,Crone ET,Moroz S,Strachan S,Vazquez M,Welbourn A

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:HIV testing is a cornerstone of efforts to combat the HIV epidemic, and testing conducted as part of surveillance provides invaluable data on the spread of infection and the effectiveness of campaigns to reduce the transmission of HIV. However, participation in HIV testing can be low, and if respondents sy...

journal_title：Journal of the International AIDS Society

authors： McGovern ME,Marra G,Radice R,Canning D,Newell ML,Bärnighausen T

更新日期：2015-11-26 00:00:00

abstract：INTRODUCTION:T cell immunoglobulin and mucin domain (Tim) 3 and programmed death 1 (PD-1) are co-inhibitory receptors involved in the so-called T cell exhaustion, and in vivo blockade of these molecules restores T cell dysfunction. High expression of Tim-3 and PD-1 is induced after chronic antigen-specific stimulation ...

journal_title：Journal of the International AIDS Society

authors： Sada-Ovalle I,Ocaña-Guzman R,Pérez-Patrigeón S,Chávez-Galán L,Sierra-Madero J,Torre-Bouscoulet L,Addo MM

更新日期：2015-10-19 00:00:00

abstract：INTRODUCTION:Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies in India are affected by attrition throughout the HIV car...

journal_title：Journal of the International AIDS Society

authors： Maddali MV,Dowdy DW,Gupta A,Shah M

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:HIV diagnoses among gay and bisexual men have increased over the past decade in Australia. HIV point-of-care testing (POCT) was introduced in Australia in 2011 as a strategy to increase HIV testing by making the testing process more convenient. We surveyed gay and bisexual men undergoing POCT to assess bar...

journal_title：Journal of the International AIDS Society

authors： Conway DP,Holt M,Couldwell DL,Smith DE,Davies SC,McNulty A,Keen P,Cunningham P,Guy R,Sydney Rapid HIV Test Study.

更新日期：2015-08-27 00:00:00

abstract：INTRODUCTION:Switching to a rilpivirine, tenofovir and emtricitabine (RTE) single-tablet regimen (STR) has been evaluated in a limited number of virologically suppressed patients. The aim of this study was to describe clinical outcomes in HIV-positive patients switched from a suppressive antiretroviral regimen to RTE S...

journal_title：Journal of the International AIDS Society

authors： Gianotti N,Poli A,Nozza S,Spagnuolo V,Tambussi G,Bossolasco S,Cinque P,Maillard M,Cernuschi M,Galli L,Lazzarin A,Castagna A

更新日期：2015-07-30 00:00:00

abstract：:Paediatric antiretroviral treatment (ART) failure is an under-recognized issue that receives inadequate attention in the field of paediatrics and within HIV treatment programmes. With paediatric ART failure rates ranging from 19.3% to over 32% in resource limited settings, a comprehensive evaluation of the causes of f...

journal_title：Journal of the International AIDS Society

authors： Bernheimer JM,Patten G,Makeleni T,Mantangana N,Dumile N,Goemaere E,Cox V

更新日期：2015-07-23 00:00:00

abstract：INTRODUCTION:To be used most effectively, pre-exposure prophylaxis (PrEP) should be prioritized to those at high risk of acquisition and would ideally be aligned with time periods of increased exposure. Identifying such time periods is not always straightforward, however. Gaza Province in southern Mozambique is charact...

journal_title：Journal of the International AIDS Society

authors： Cremin I,Morales F,Jewell BL,O'Reilly KR,Hallett TB

更新日期：2015-07-20 00:00:00

abstract：INTRODUCTION:HIV incidence remains high among young women in sub-Saharan Africa in spite of scale-up of HIV testing, behavioural interventions, antiretroviral treatment and medical male circumcision. There is a critical need to critique past approaches and learn about the most effective implementation of evidence-based...

journal_title：Journal of the International AIDS Society

authors： Celum CL,Delany-Moretlwe S,McConnell M,van Rooyen H,Bekker LG,Kurth A,Bukusi E,Desmond C,Morton J,Baeten JM

更新日期：2015-07-20 00:00:00

abstract：INTRODUCTION:Evidence suggests that people who inject drugs often begin their drug use and injecting practices in adolescence, yet there are limited data available on the HIV epidemic and the responses for this population. The comprehensive package of interventions for the prevention, treatment and care of HIV infectio...

journal_title：Journal of the International AIDS Society

authors： Krug A,Hildebrand M,Sun N

更新日期：2015-02-26 00:00:00

abstract：INTRODUCTION:Mortality among HIV-positive adults awaiting antiretroviral therapy (ART) has previously been found to be high. Here, we compare adolescent pre-ART mortality to that of adults in a public sector HIV care programme in Bulawayo, Zimbabwe. METHODS:In this retrospective cohort study, we compared adolescent pr...

journal_title：Journal of the International AIDS Society

authors： Shroufi A,Ndebele W,Nyathi M,Gunguwo H,Dixon M,Saint-Sauveur JF,Taziwa F,Viñoles MC,Ferrand RA

更新日期：2015-02-23 00:00:00

abstract：INTRODUCTION:Injecting drug use (IDU) is associated with tuberculosis but few data are available from low-income settings. We examined IDU in relation to active and latent tuberculosis (LTBI) among HIV-positive individuals in Indonesia, which has a high burden of tuberculosis and a rapidly growing HIV epidemic strongly...

journal_title：Journal of the International AIDS Society

authors： Meijerink H,Wisaksana R,Lestari M,Meilana I,Chaidir L,van der Ven AJ,Alisjahbana B,van Crevel R

更新日期：2015-02-16 00:00:00

abstract：INTRODUCTION:Within monocyte-derived macrophages, HIV-1 accumulates in intracellular virus-containing compartments (VCCs) that are inaccessible to the external environment, which implicate these cells as latently infected HIV-1 reservoirs. During mother-to-child transmission of HIV-1, human placental macrophages (Hofba...

journal_title：Journal of the International AIDS Society

authors： Johnson EL,Chu H,Byrareddy SN,Spearman P,Chakraborty R

更新日期：2015-01-22 00:00:00

abstract：INTRODUCTION:Every year, approximately 260,000 children are infected with HIV in low- and middle-income countries. The timely initiation and high level of maintenance of antiretroviral therapy (ART) are crucial to reducing the suffering of HIV-positive children. We need to develop a better understanding of the backgrou...

journal_title：Journal of the International AIDS Society

authors： Kikuchi K,Poudel KC,Muganda J,Sato T,Mutabazi V,Muhayimpundu R,Majyambere A,Nyonsenga SP,Sase E,Jimba M

更新日期：2014-12-03 00:00:00

abstract：INTRODUCTION:A key objective of combined antiretroviral therapy (cART) is to reach and maintain high CD4 cell counts to provide long-term protection against AIDS-defining opportunistic infections and malignancies, as well as other comorbidities. However, a high proportion of patients present late for care. Our objectiv...

journal_title：Journal of the International AIDS Society

authors： Costagliola D,Lacombe JM,Ghosn J,Delaugerre C,Pialoux G,Cuzin L,Launay O,Ménard A,de Truchis P,Mary-Krause M,Weiss L,Delfraissy JF

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Lamivudine (3TC) and emtricitabine (FTC) are considered interchangeable by HIV-1 guidelines in first-line tenofovir/efavirenz (TDF/EFV) and TDF/nevirapine (NVP) combination antiretroviral therapy (cART). Data from trials on equivalence of 3TC and FTC are inconsistent. We examined the effectiveness of 3TC a...

journal_title：Journal of the International AIDS Society

authors： Rokx C,Fibriani A,van de Vijver D,Verbon A,Schutten M,Gras L,Rijnders BJ

更新日期：2014-11-02 00:00:00

abstract：:Eastern Europe and Central Asia have the largest drug epidemic globally and the fastest and still expanding HIV epidemic. The Russian Federation and Ukraine together account for over 90% of the reported AIDS cases in the region. If small in absolute numbers, the epidemics are however significant in prevalence rate in ...

journal_title：Journal of the International AIDS Society

authors： Kazatchkine M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The evolving HIV epidemic, coupled with advances in HIV treatment, has resulted in an ageing HIV-diagnosed population. It has been suggested that adverse physical and psychological effects of HIV may be higher among older people. However, few studies have examined the effect of older age on well-being for ...

journal_title：Journal of the International AIDS Society

authors： McGowan J,Sherr L,Rodger A,Fisher M,Miners A,Johnson M,Elford J,Collins S,Hart G,Phillips A,Speakman A,Lampe F

更新日期：2014-11-02 00:00:00

abstract：:Prevention of HIV infection has recently acquired new effective tools, based on the provision of antiretrovirals, to both decrease the "source" of HIV infection and/or to decrease host susceptibility to HIV infection. The milestone concept of using antiretrovirals for prevention has been tested already in the 1990s, t...

journal_title：Journal of the International AIDS Society

authors： Vella S

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Cenicriviroc (CVC), a once-daily, dual CCR5/CCR2 co-receptor antagonist, has completed Phase 2b development. CVC demonstrated favourable safety and similar efficacy compared with efavirenz (EFV) in Study 202 (NCT01338883); an ex vivo sub-analysis evaluated treatment effects on HIV entry, measured by intrac...

journal_title：Journal of the International AIDS Society

authors： Kramer V,Hassounah S,Colby-Germinario S,Mesplède T,Lefebvre E,Wainberg M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Cardiovascular diseases are increasing in aging HIV-positive patients (HIV+). Impact of traditional cardiovascular risk factors, HIV-specific parameters and antiretroviral therapy (ART) on the incidence of cardiovascular events (CVE) and on the mortality rate are investigated in different HIV+ cohorts. ME...

journal_title：Journal of the International AIDS Society

authors： Esser S,Eisele L,Schwarz B,Schulze C,Holzendorf V,Brockmeyer NH,Hower M,Kwirant F,Rudolph R,Neumann T,Reinsch N

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Lipodystrophy is still a matter of concern in HIV+ patients receiving ART. However, long-term fat change in patients taking non-thymidine regimens is not well known. MATERIALS AND METHODS:A prospective ongoing fat change assessment including clinical evaluation and dexa scans (Hologic QDR 4500) is being c...

journal_title：Journal of the International AIDS Society

authors： Ferrer E,Navarro A,Curto J,Medina P,Rozas N,Barrera G,Saumoy M,Tiraboschi JM,Gomez C,Podzamczer D

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Transmission in serodiscordant couples (SDCs) accounts for approximately half of all new HIV infections, both in Kenya and the wider sub-Saharan region (1). With evidence to suggest inconsistent condom use within this population (2), the World Health Organization has recommended two new methods of HIV prev...

journal_title：Journal of the International AIDS Society

authors： Fowler N,Arkell P,Abouyannis M,James C,Roberts L

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:This descriptive, non-interventional study on HIV-1-infected patients treated with DRV/r in the usual clinical setting, with a single-arm prospective observational design, collected data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in marketing authorization in usual clinica...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Borderi M,Cauda R,Bini T,Chirianni A,Squillace N,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Dolutegravir (DTG) is an HIV integrase strand transfer inhibitor approved for use in combination with other antiretrovirals for the treatment of HIV-infection in adults and adolescents. Metformin is a drug frequently used in diabetic HIV-infected patients, which requires titration to optimize dosing. In vi...

journal_title：Journal of the International AIDS Society

authors： Zong J,Borland J,Jerva F,Wynne B,Choukour M,Song I

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Routes of transmission and reasons for HIV testing are important epidemiologic data to analyze the epidemic and to tailor the response to AIDS. The aim of this study was to analyze reasons for testing and transmission ways of HIV among recently diagnosed HIV patients registered in the multicenter HIV-TR co...

journal_title：Journal of the International AIDS Society

authors： Dokuzoguz B,Korten V,Gökengin D,Fincanci M,Yildirmak T,Kes UN,Tasdelen Fisgin N,Inan D,Eraksoy H,Akalin H

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Although RTS as HIV Diagnosis was considered cost effectiveness [1], overall budget may be unaffordable for some countries. We explore Incremental cost per NDHI associated with different TS. MATERIALS AND METHODS:From a health care perspective, using direct costs and Euros currency, we calculated budget a...

journal_title：Journal of the International AIDS Society

authors： Gomez-Ayerbe C,Elías MJ,Muriel A,Elías PP,Cano A,Diaz A,Moreno A,Casado JL,Santos C,Martinez-Colubi M,Uranga A,Dronda F,Moreno S

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Global HIV-1 prevalence is 35.3 million [1]; women comprise >50% of those infected. The majority of women may lack regular care and only one-fourth are virologically suppressed [2]. ELLA is a cross-sectional, non-interventional study conducted across Europe, Latin America, Canada and Asia that describes ba...

journal_title：Journal of the International AIDS Society

authors： Baran R,Mulcahy F,Krznaric I,Monforte Ad,Samarina A,Xi H,Cassetti I,Madruga JV,Zachry W,van Wyk J,Martinez M

更新日期：2014-11-02 00:00:00